Faculty Interests Database

Faculty Affairs: Faculty Interests Database Noreen J. Hickok, Ph.D.

Orthopaedic Surgery
Thomas Jefferson University
Jefferson Medical College
Department of Orthopaedic Surgery
Associate Professor

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Mailing Address Contact Information
233 S 10th Street
Philadelphia, Pennsylvania 19107
United States
Phone: (215) 955-6979

Expertise and Research Interests
Infection following placement of therapeutic implants is a devastating complication that results in pain, increased disability, and the need for aggressive therapeutic intervention. This implant-associated infection is very recalcitrant to treatment with antibiotics. Firstly, bacteria adhere to and secrete a biofilm on metallic surfaces, embedding the bacteria within a matrix that limits accessibility by antibiotics and/or immune surveillance. Secondly, eukaryotic cells can harbor viable bacteria, allowing establishment of latent infections. Current research efforts are centered around strategies to subvert the ability of microorganisms to colonize these implants, as well as to prevent their propagation in the space immediately surrounding the implant. Specifically, we have discovered that we can decorate the surfaces of metal implants with antibiotics and other anti-microbial agents to produce an implant that is resistant to colonization by bacteria. Currently, we are expanding the ability of the implant surface to be an active anti-infective agent while maximizing its biocompatibility. In parallel, we are investigating mechanisms of bacteria colonization of eukaryotic cells and how to harness the cells machinery to eliminate internalized bacteria. These studies span fields related to bioengineering, tissue engineering, biochemistry, and biology to produce new translational products that can improve the outcome of implantations.
Antimicrobial; Antibiotic; Bacteria; Biofilm; Biomarker; Bone Diseases; Chondrocytes; Genetic Regulation; Immunoprecipitation; Implant-associated Infection; Infection; Messenger RNA; Musculoskeletal System; Osteoblast; Prosthesis; Staphylocci Aureus; Skeletal Disease; Skin Diseases; Tissue Cell Culture; Transfection
  • V. Antoci, Jr., S.B. King, B. Jose, J. Parvizi, A.R. Zeiger, E. Wickstrom, T.A. Freeman, R.J. Composto, P. Ducheyne, I.M. Shapiro, N.J. Hickok, C.S. Adams. Vancomycin covalently bonded to titanium alloy prevents bacterial colonization. J. Orthop. Res., 7:858-866, 2007.
  • Antoci, V., Jr., Adams, C.S., Hickok, N.J., Shapiro, I.M., Parvizi J. Antibiotics for local delivery systems cause skeletal cell toxicity in vitro. Clin. Orthop. Rel. Res. 462:200-206, 2007.
  • Antoci, V., Jr., Adams, C.S., Hickok, N.J., Shapiro, I.M., Parvizi J. Vancomycin bound to Ti rods reduces periprosthetic infection: preliminary study. Clin. Orthop. Rel. Res. 461:88-95, 2007.
  • Antoci, V., Jr., Adams, C.S., Parvizi, J., Ducheyne, P., Shapiro, I.M., Hickok, N.J. Covalently attached vancomycin provides a nanoscale antibacterial surface. Clin. Orthop. Rel. Res. 461:81-87, 2007
  • S. Radin, V. Antoci, Jr., N.J. Hickok, C.S. Adams, J. Parvizi, I.M. Shapiro, P. Ducheyne. In vitro and in vivo bactericidal effect of sol-gel antibiotic thin films on fixation devices. Key Engineering Materials 330-332:1323-1325, 2007.
  • F. Han, J.R. Gilbert, C.S. Adams, G. Harrison, T.A. Freeman, Z. Tao, R. Zaka, H. Liang, C. Williams, R.S. Tuan, P.A. Norton, N.J. Hickok. Transforming Growth Factor ²1 regulates fibronectin isoforms expression and splicing factor SRp40 expression during ATDC5 chondrogenic maturation. Exp. Cell Res., 313:1518-1532, 2007.
  • Parvizi, J., Antoci, V., Jr., Hickok, N.J., Shapiro, I.M. Selfprotective smart orthopedic implants. Expert. Rev. Med. Devices, 4:55-64, 2007.
  • Edupuganti OP, Antoci V Jr, King SB, Jose B, Adams CS, Parvizi J, Shapiro IM, Zeiger AR, Hickok, NJ, Wickstrom E.Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization. Bioorg Med Chem Lett. 2007 May 15;17(10):2692-6. Epub 2007 Mar 7

Last Updated by Noreen Hickok, Ph.D.: Friday, April 12, 2013 11:51:45 AM

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