Faculty Interests Database

Faculty Affairs: Faculty Interests Database Michael Oshinsky

Associate Professor
Appointed: 2002
Thomas Jefferson University
Jefferson Medical College
Department of Neurology

Jefferson Headache Center
Director, Preclinical Research
Mailing Address Contact Information
1020 Locust St., Suite 398 JAH
Philadelphia, Pennsylvania 19107
United States
Phone: 215-955-0433
Fax: 215-955-4878
Academic Positions:
2001 - 2006 Research Assistant Professor, Department of Neurology
2006 - 2012 Assistant Professor (tenure track), Department of Neurology
2012 -  Associate Professor (tenure track), Department of Neurology

Hospital and Administrative Appointments:
2003 - Director of Preclinical Research, Jefferson Headache Center
2009 - Member, Daniel Baugh Institute for Functional Genomics/Computational Biology

1998 - 2000 post-doc University of Pennsylvania, Laboratory of Neuromodulation and Behavior
Post-Doctoral Research Associate, Department of Psychiatry
NIH NRSA Post-Doctural Fellow, University of Pennsylvania, Section of Neuromodualtion and Behavior

1998 Ph.D., Cornell University, Neurobiology and Behavior

2000 B.A., Brandeis University, Biology, Cum Laude, High Honors in Neuroscience)

Expertise and Research Interests
Recurrent episodic headache syndromes, such as migraine, are the most common pain-related complaint seen in medical practice, accounting for 18 million physician visits each year. These primary headache disorders are responsible for >$16 billion in lost productivity in the U.S. each year. Migraine is more than just episodic headache. Migraine is a neurologic disorder characterized by periodic attacks of head pain, as well as nausea, vomiting, phonophobia, photophobia, and allodynia. Even when migraine patients have not had an attack in weeks, physiological and biochemical abnormalities are present. Migraineurs also have significant sensory processing abnormalities, such as a lack of habituation to repeated stimuli, even when they do not have head pain.

Our lab is investigating a new model of recurrent headache in rat. This model uses repeated inflammatory dural stimulation to mimic the repeated activation of dural afferents believed to occur in patients with recurrent migraine headache. After multiple inflammatory stimulations of the dura, there is an unique physiological state generated in the rats that is stable, and long outlasts the last stimulation. This state is characterized by sensory and physiological hyperresponsiveness of the trigeminal neurovascular system that significantly differs from the relatively short lasting and smaller magnitude changes induced by a single acute stimulation of the dura.

Rats that have received many simulated headaches display behaviors and sensory changes similar to the associated symptoms and comorbid clinical conditions of migraine patients. We use electrophysiology, microdialysis, immunohistochemistry and behavior to quantify and assess the mechanism by which repeated trigeminal nociceptive stimulation causes long-lasting physiological changes that parallel the interictal physiological abnormalities of migraineurs.
Headache, Migraine, Trigeminal Pain, Animal Models, Electrophysiology, Microdialysis, Quantitative Sensory Testing, Chronic Headache, Hormones and Pain, Mitochondria and Pain, Circadian Rythms, Computational Neural Circuits
  • Oshinsky M.L., Sensitization and ongoing activation in the trigeminal nucleus caudalis, PAIN, Available online 4 April 2014, http://dx.doi.org/10.1016/j.pain.2014.04.001.
  • Oshinsky, M.L., Murphy, A.L., Hekierski Jr., H., Cooper, M., Simon, B.J. Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia (2014) Pain, 155 (5), pp. 1037-1042. DOI: 10.1016/j.pain.2014.02.009.
  • Oshinsky, M.L., Sanghvi, M.M., Maxwell, C.R., Gonzalez, D., Spangenberg, R.J., Cooper, M., Silberstein, S.D. Spontaneous trigeminal allodynia in rats: A model of primary headache (2012) Headache, 52 (9), pp. 1336-1349. doi: 10.1111/j.1526-4610.2012.02247.x.
  • Hirata, H., Fried, N., Oshinsky, M.L. Quantitative characterization reveals three types of dry-sensitive corneal afferents: pattern of discharge, receptive field, thermal and chemical sensitivity. J. Neurophysiology. J Neurophysiol. 107 (4), pp. 1199-1209.
  • Elliott, M.B., Silberstein, S.D., Oshinsky, M.L. Pre-clinical Research of Post-Traumatic Headache with Migrainous Features. International Neurotrauma Letter, Issue 1, 2012.
  • Elliott, M.B. Michael L. Oshinsky, Peter S. Amenta1, Olatilewa O. Awe. Jack I. Jallo. Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury. Headache. 2012 Jun;52(6):966-84. doi: 10.1111/j.1526-4610.2012.02160.x.
  • Hirata, H., Oshinsky, M.L. Response characteristics of the corneal afferent neurons that are excited by drying of the cornea and are implicated in basal tearing in rats. J Neurophysiol 107: 1199 1209, 2012. doi:10.1152/jn.00657.2011.
  • Maxwell CR, Spangenberg RJ, Hoek JB, Silberstein SD, Oshinsky ML. 2010 Acetate Causes Alcohol Hangover Headache in Rats. PLoS ONE 5(12): e15963. doi:10.1371/journal.pone.0015963.
  • Ashkenazi A, Yang I, Mushtaq A, Oshinsky ML. Is phonophobia associated with cutaneous allodynia in migraine. (2010) J Neurol Neurosurg Psychiatry. Journal of Neurology, Neurosurgery and Psychiatry 81 (11), pp. 1256-1260.
  • Hussain A, Stiles MA, Oshinsky ML. Pain remapping in migraine: A novel characteristic following trigeminal nerve injury. (2010) Headache. Vol. 50:4. pp. 669-674.
  • Monteith, T.S., Oshinsky, M.L. Tension-type Headache With Medication Overuse: Pathophysiology and Clinical Implications. (2009) Current Pain & Headache Reports, vol.13:6. pp. 463-469.
  • Ashkenazi A, Mushtaq A, Yang I, Oshinsky ML. Ictal and interictal phonophobia in migraine  a quantitative controlled study. (2009) Cephalalgia 29:10. pp. 1042-1048.
  • Piovesan, E.J., Randunz, V., Utiumi, M., Lange, M.C., Kowacs, P.A., Mulinari, R.A., Oshinsky, M.L., Vital, M., Sereniki, A., Fernandes, A.F., Silva, L.L., Werneck, L.C. Influence of NMDA and non-NMDA antagonists on acute and inflammatory pain in the trigeminal territory: A placebo control study (2008) Arquivos de Neuro-Psiquiatria, 66 (4), pp. 837-843.
  • Farris HE, Oshinsky ML, Forrest TG, Hoy RR: Auditory Sensitivity of an Acoustic Parasitoid(Emblemasoma sp., Sarcophagidae, Diptera) and the Calling Behavior of Potential Hosts. Brain Behav Evol 2008;72:16-26
  • Oshinsky ML, Gomonchareonsiri S, Luo J. Episodic Dural Stimulation in Awake Rats: A Model for Recurrent Headache. Headache. 2007; 47:1026-1036.
  • Oshinsky ML. Pozo-Rosich P. Dihydroergotamine Blocks the Induction of and Reverses Sensitization in a rat Model of Migraine. Submitted: Annals of Neurology.
  • Oshinsky ML. Insights from Experimental Studies into Allodynia and its Treatment. Current Pain and Headache Reports. 2006;10:225-230.
  • Oshinsky ML, Luo J. Neurochemistry of Trigeminal Activation in an Animal Model of Migraine. Headache.2006;46: S39-S44.
  • Mason AC, Lee N, Oshinsky ML. The start of phonotactic walking in the fly Ormia ochracea: a kinematic study. J Exp Biol. 2005 Dec 15;208(Pt 24):4699-708.
  • Young WB, Oshinsky ML, Shechter AL, Gebeline-Myers C, Bradley KC, Wassermann EM. Consecutive Transcranial Magnetic Stimulation: Phosphene Thresholds in Migraineurs and Controls. Headache. 2004 Feb;44(2):131-135.
  • Oshinsky M.L. Botulinum Toxins and Migraine: How does it work? Practical Neurology, June 2004, suppl., pp. 10-13.
  • Piovesan EJ, Kowacs PA, Oshinsky ML. Convergence of cervical and trigeminal sensory afferents. Curr. Pain Headache Rep. 2003 Oct;7(5):377-83.
  • Piovessan EJ, Young BW, Werneck LC, Kowacs PA, Oshinsky ML, Silberstein SD. Recurrent Extratrigeminal Stabbing and Burning Sensation with Allodynia in a Migraine Patient. Cephalalgia 2003 Apr;23(3):231-234.
  • Luo J, Kaplitt MG, Fitzsimons HL, Zuzga D, Liu Y, Oshinsky ML,1 During MJ. Subthalamic GAD Gene Therapy in a Parkinsons Disease Model. Science 2002 October 11; 298: 425-429.
  • Oshinsky ML., Hoy RR. Physiology of the acoustic afferents in the parasitoid fly, Ormia ochracea. J Neurosci 2002 Aug 15;22(16):7254-63.
  • Rozen TR, Oshinsky ML, Gebeline CA, Bradely K, Young WB, Silberstein SD. (2002) Open Label Trial of Coenzyme Q10 as a Migraine Preventive. Cephalalgia. 2002 Mar;22(2):137-41.
  • Aston-Jones G, Chen S, Zhu Y and Oshinsky ML. (2001) A Neural Circuit for Circadian Regulation of Arousal. Nature Neuroscience, 2001 Jul; 4(7):732-8.
  • Mason AC., Oshinsky ML., and Hoy RR. Hyperacute directional hearing in a microscale auditory system. Nature. 2001 Apr 5;410(6829):686-90.
  • Peres MF, Stiles MA, Oshinsky ML, Rozen TD. Remitting Form of Hemicrania Continua with Seasonal Pattern (circannual variation). Headache. 2001 Jun; 41(6):592-4.
  • Christie A.E., Hall C., Oshinsky M.L. (1994) Buccalin-like and Myomodulin-Like Peptide in the Stomatogastric Ganglion of the Crab Cancer borealis. J Exp Biol. 1994 Aug;193:337-43.
  • Goadsby P.J., Oshinsky, M.L. (2008) Pathophysiology of Headache. In: Wolff's Headache and Other Head Pain. 8th Edition. Ed. Silberstein, Lipton, Dodick. Oxford Press.
  • Oshinsky M.L. (2006) Headache Pathogenesis. In: Neurology Basic and Clinical Neurosciences. Ed. Anthony H.V. Schapira. Mosby-Elsevier.
  • Oshinsky M.L. (2005) Pathophysiology of Migraine. In: Visual Atlas of Migraine and other Headaches. Sec. Edition. Ed: Silberstein, Stiles and Young. Taylor and Francis Group.
  • Oshinsky M.L., Silberstein S.D. (2003) Pathophysiology of Migraine Preventatives. CD-ROM. New Jersey, Health Learning Systems.
  • Oshinsky M.L., Silberstein S.D. (2001) Pathophysiology of Migraine. CD-ROM. New Jersey, Health Learning Systems
  • Oshinsky M.L., Marder E. (1992) A Model of the Oscillatory Properties of a Muscle Fiber due to Peptide Modulation. Quadrivium. vol. 1:2 pp. 13-15.

Last Updated by Michael Oshinsky: Tuesday, December 4, 2012 5:48:50 PM

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