Faculty Affairs: Faculty Interests Database
Melanie B Elliott
Department of Neurological Surgery
Department of Neuroscience
|Mailing Address||Contact Information|
1020 Locust Street
Philadelphia, Pennsylvania 19107
|Ph.D., Temple University, 2005
M.Ed., Temple University, 2000
|Expertise and Research Interests|
|Past research experience includes twelve years studying mild to moderate traumatic brain injuries including concussion and pain
for eight years. Research by my laboratory investigates dysfunctional brain circuitry and degenerative processes in the injured
brain that contribute to post-traumatic neurological and cognitive disorders. My particular interests span several post-traumatic
disorders such as pain, post-traumatic stress disorder, sleep disturbances, and memory and learning deficits. A variety of
techniques such as immunohistochemistry, RT-PCR, ELISA and western blot in conjunction with genetic and/or pharmacologic
manipulation are utilized by my laboratory.
A main area of research involves the sensitization of the neurons within the pain pathway after traumatic brain injury with
implications in the treatment of post-traumatic migraine.
We also study anti-inflammatory and glial modulation as targeted neuroprotective strategies for traumatic brain injury. We are
particularly interested in the involvement of an endogenous neurotransmitter system, the endocannabinoid system, which has a
known role in both pathological and homeostatic functions in the injured CNS.
Research support: Merck Inc.; Department of Defense
|brain injury; head trauma; headache; glia; inflammation; endocannabinoid system|
Last Updated by Melanie Elliott: Tuesday, October 9, 2012 11:09:08 AM