Faculty Affairs: Faculty Interests Database
Melanie B Elliott

Neurosurgery
Assistant Professor

Department of Neurological Surgery

Department of Neuroscience
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Mailing Address Contact Information
1020 Locust Street
Philadelphia, Pennsylvania 19107
United States
Phone: 215-955-3776
melanie.elliott@jefferson.edu
Qualifications
Ph.D., Temple University, 2005
M.Ed., Temple University, 2000
Expertise and Research Interests
Past research experience includes twelve years studying mild to moderate traumatic brain injuries including concussion and pain
for eight years. Research by my laboratory investigates dysfunctional brain circuitry and degenerative processes in the injured
brain that contribute to post-traumatic neurological and cognitive disorders. My particular interests span several post-traumatic
disorders such as pain, post-traumatic stress disorder, sleep disturbances, and memory and learning deficits. A variety of
techniques such as immunohistochemistry, RT-PCR, ELISA and western blot in conjunction with genetic and/or pharmacologic
manipulation are utilized by my laboratory.

A main area of research involves the sensitization of the neurons within the pain pathway after traumatic brain injury with
implications in the treatment of post-traumatic migraine.

We also study anti-inflammatory and glial modulation as targeted neuroprotective strategies for traumatic brain injury. We are
particularly interested in the involvement of an endogenous neurotransmitter system, the endocannabinoid system, which has a
known role in both pathological and homeostatic functions in the injured CNS.

Research support: Merck Inc.; Department of Defense
Keywords
brain injury; head trauma; headache; glia; inflammation; endocannabinoid system
Publications
  • Amenta, P.A., Jallo, J.I., Tuma, R.F., Elliott, M.B. A cannabinoid type-2 receptor agonist attenuates blood-brain-barrier damage and neurodegeneration in a murine model of traumatic brain injury, Journal of Neuroscience Research, 2012. doi: 10.1002/jnr.23114. [Epub ahead of print].
  • Elliott, M.B., Oshinsky, M.L., Amenta, P.S., Awe, O.O., Jallo, J.I. Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury. Headache, 52: 966-984, 2012.
  • Elliott, M.B., Silberstein, S.D., Oshinsky, M.L. 2012. Pre-clinical Research of Post-Traumatic Headache with Migrainous Features. International Neurotrauma Letter, Issue 1, 2012.
  • Elliott, M.B., Tuma, R.F., Jallo, J.I. Advancing the Treatment of Traumatic and Ischemic Brain Injuries: Modulation of the Endocannabinoid System. In K. Baker and N. Edwards (Eds.) Brain Injuries: New Research. Hauppauge NY: Nova Publishers. 2012.
  • Elliott MB, Barbe MF. Understanding Pain Mechanisms: The Basis of Clinical Decision Making for Pain Modulation; Chapter 113. In: Rehabilitation of the hand and upper extremity. 6th edition. Fedorczyk and Skirven (Editors), Elsevier: Ontario. 2011.
  • Elliott, MB, Tuma, RF, Amenta, PA, Barbe, MB, Jallo, JI. Acute effects of a selective cannabinoid-2 receptor agonist on neuroinflammation in a murine model of traumatic brain injury, Journal of Neurotrauma, 28, 973-981, 2011.
  • Levene, HB, Elliott, MB, Gaughan, JP, Loftus, CM, Tuma, RF, Jallo, JI. A murine model of hypertonic saline as a treatment for acute spinal cord injury: effects on autonomic outcome. Journal of Neurosurgery: Spine, Jan14: 131-138, 2011.
  • Elliott, MB. Barr, AE, Clark, BD, Wade, CK, Barbe, MF. Performance of a repetitive task by aged rats leads to median neuropathy and spinal cord inflammation with associated sensorimotor declines. Neuroscience, 170, 929-941, 2010.
  • Elliott, MB, Jallo, JI, Barbe, MF, Tuma, RF. Hypertonic saline attenuates tissue loss and astrocyte hypertrophy in a model of traumatic brain injury. Brain Research, 305: 183-191, 2009.
  • Elliott MB, Barr AE, Barbe MF. Spinal substance P and neurokinin-1 increase with high repetition reaching. Neuroscience Letters, 454(1): 33-37, 2009.
  • Elliott MB, Barr AE, Clark BD, Amin M, Amin S, Barbe MF. High force reaching task induces widespread inflammation, increased spinal cord neurochemicals and neuropathic pain. Neuroscience, 158(2): 922-31, 2009.
  • Elliott MB, Jallo JJ, Tuma RF. An investigation of cerebral edema and injury volume assessments for controlled cortical impact injury. Journal of Neuroscience Methods, 168: 320-324, 2008.
  • Barbe MF, Elliott MB, Abdelmagid S, Safadi FF, Popoff SN, Amin M, Barr AE. Serum and tissue cytokines and chemokines increase with repetitive upper extremity tasks. J Orthop Res.,26 (10):1320-6, 2008.
  • Elliott MB, Barr AE, Kietrys DM, Al-Shatti T, Amin M, Barbe MF. Peripheral neuritis and changes in spinal cord neurochemicals are induced in a model of repetitive motion injury with low force and repetition exposure. Brain Research 1218: 103-113, 2008.
  • Elliott MB, Jallo JJ, Gaughan JP, Tuma RF. Effects of Crystalloid-Colloid Solutions on Traumatic Brain Injury. Journal of Neurotrauma, 24 (1): 195-202, 2007.

Last Updated by Melanie Elliott: Tuesday, October 9, 2012 11:09:08 AM

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