Faculty Affairs: Faculty Interests Database
Louise Y.Y. Fong

Pathology, Anatomy & Cell Biology
Thomas Jefferson University
Jefferson Medical College
Associate Professor

Mailing Address Contact Information
Rm 473 JAH, 1020 Locust Street
Philadelphia, Pennsylvania 19107
United States
Phone: 215-955-5616
Louise.Fong@jefferson.edu
Keywords
Dietary zinc; oral-esophageal cancer; prostate cancer; lung cancer; inflammation; chemoprevention; transcriptome profiling; microrna
Publications
  • Selected Publications
  • Alder H, Taccioli C, Chen H, Jiang Y, Smalley KJ, Fadda P, Ozer HG, Huebner K, Farber JL, Croce CM, Fong LY. Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer. Carcinogenesis. 2012 Jun 10.doi: 10.1093/carcin/bgs204. [Epub ahead of print].
  • Taccioli C, Chen H, Jiang Y, Liu XP, Huang K, Smalley KJ, Farber JL, Croce CM, Fong LY. Dietary zinc deficiency fuels esophageal cancer development by inducing a distinct inflammatory signature. Oncogene. 2011 Dec 19. doi: 10.1038/onc.2011.592. [Epub ahead of print].
  • Fong LY, Jiang Y, Rawahneh ML, Croce CM, Farber JL, Huebner K. Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induce rat oral carcinogenesis. Carcinogenesis. 32(4):554-60, 2011.
  • Sun J, Liu J, Pan X, Quimby D, Zanesi N, Druck T, Pfeifer GP, Croce CM, Fong LY, Huebner K. Effect of Zinc Supplementation on N-nitrosomethylbenzylamine-induced forestomach tumor development and progression in tumor suppressor-deficient mouse strains. Carcinogenesis. 32(3):351-8, 2011.
  • Wan SG, Taccioli C, Jiang Y, Chen H, Smalley KJ, Huang K, Liu XP, Farber JL, Croce CM, Fong LY. Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression. Int J Cancer. 129(2):331-45, 2011.
  • Sun J, Okumura H, Yearsley M, Frankel W, Fong LY, Druck T, Huebner K. Nit1 and Fhit tumor suppressor activities are additive. J Cell Biochem. 107(6):1097-106, 2009.
  • Taccioli C, Wan SG, Liu CG, Alder H, Volinia S, Farber JL, Croce CM, Fong LY. Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat. Gastroenterology. 136(3):953-66, 2009.
  • Fong LY, Jiang Y, Riley M, Liu X, Smalley KJ, Guttridge DC, Farber JL. Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2. Int J Cancer. 122(5):978-89, 2008.
  • Aqeilan RI, Hagan JP, Aqeilan HA, Pichiorri F, Fong LY, Croce CM. Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo. Cancer Res. 67(12):5606-10, 2007.
  • Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM. Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. Cancer Cell. 11(3):275-89, 2007.
  • Fong LY, Jiang Y, Farber JL. Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice. Carcinogenesis. 27(7):1489-96, 2006.
  • Liu CG, Zhang L, Jiang Y, Chatterjee D, Croce CM, Huebner K, Fong LY. Modulation of gene expression in precancerous rat esophagus by dietary zinc deficit and replenishment. Cancer Res. 65(17):7790-9, 2005.
  • Drusco A, Zanesi N, Roldo C, Trapasso F, Farber JL, Fong LY, Croce CM. Knockout mice reveal a tumor suppressor function for Testin. Proc Natl Acad Sci U S A. 102(31):10947-51, 2005.
  • Guler G, Iliopoulos D, Han SY, Fong LY, Lubet RA, Grubbs CJ, Huebner K. Hypermethylation patterns in the Fhit regulatory region are tissue specific. Mol Carcinog. 43(3):175-81, 2005.
  • Fong LY, Zhang L, Jiang Y, Farber JL. Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. J Natl Cancer Inst. 97(1):40-50, 2005.
  • Lubet RA, Huebner K, Fong LY, Altieri DC, Steele VE, Kopelovich L, Kavanaugh C, Juliana MM, Soong SJ, Grubbs CJ. 4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin. Carcinogenesis. 26(3):571-8, 2005.
  • Ishii H, Vecchione A, Furukawa Y, Croce CM, Huebner K, Fong LY. Differentially expressed genes execute zinc-induced apoptosis in precancerous esophageal epithelium of zinc-deficient rats. Oncogene. 23(49):8040-8, 2004.
  • Han SY, Iliopoulos D, Druck T, Guler G, Grubbs CJ, Pereira M, Zhang Z, You M, Lubet RA, Fong LY, Huebner K. CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors. Oncogene. 23(22):3990-8, 2004.
  • Ishii H, Zanesi N, Vecchione A, Trapasso F, Yendamuri S, Sarti M, Baffa R, During MJ, Huebner K, Fong LY, Croce CM. Regression of upper gastric cancer in mice by FHIT gene delivery. FASEB J. 17(12):1768-70, 2003.
  • Fong LY, Mancini R, Nakagawa H, Rustgi AK, Huebner K. Combined cyclin D1 overexpression and zinc deficiency disrupts cell cycle and accelerates mouse forestomach carcinogenesis. Cancer Res. 63(14):4244-52, 2003.
  • Fong LY, Feith DJ, Pegg AE. Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis. Cancer Res. 63(14):3945-54, 2003.
  • Fong LY, Ishii H, Nguyen VT, Vecchione A, Farber JL, Croce CM, Huebner K. p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice. Cancer Res. 63(1):186-95, 2003.
  • Fong LY, Nguyen VT, Farber JL. Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc. J Natl Cancer Inst. 93(20):1525-33, 2001.
  • Fong LY, Nguyen VT, Pegg AE, Magee PN. Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats. Cancer Epidemiol Biomarkers Prev. 10(3):191-9, 2001.
  • Dumon KR, Ishii H, Fong LY, Zanesi N, Fidanza V, Mancini R, Vecchione A, Baffa R, Trapasso F, During MJ, Huebner K, Croce CM. FHIT gene therapy prevents tumor development in Fhit-deficient mice. Proc Natl Acad Sci U S A. 98(6):3346-51, 2001.
  • Fong LY, Nguyen VT, Farber JL, Huebner K, Magee PN. Early deregulation of the the p16ink4a-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway in cell proliferation-driven esophageal tumorigenesis in zinc-deficient rats. Cancer Res. 60(16):4589-95, 2000.
  • Fong LY, Fidanza V, Zanesi N, Lock LF, Siracusa LD, Mancini R, Siprashvili Z, Ottey M, Martin SE, Druck T, McCue PA, Croce CM, Huebner K. Muir-Torre-like syndrome in Fhit-deficient mice. Proc Natl Acad Sci U S A. 97(9):4742-7, 2000.
  • Fong LY, Magee PN. Dietary zinc deficiency enhances esophageal cell proliferation and N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumor incidence in C57BL/6 mouse. Cancer Lett. 143(1):63-9, 1999.

Last Updated by Louise Fong: Wednesday, June 13, 2012 12:16:07 PM

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