Faculty Affairs: Faculty Interests Database Jan B. Hoek, Ph.D.
Pathology, Anatomy & Cell Biology
|Mailing Address||Contact Information|
1020 Locust Street JAH 269
Philadelphia, Pennsylvania 19107
Phone: (215) 503-5016
|Ph.D., University of Amsterdam, 1972
|Expertise and Research Interests|
|Research in my laboratory is focused on the analysis of integrated signaling responses in liver and other tissues and on the adaptive or maladaptive modification of these responses by acute and chronic ethanol exposure. The following project are currently ongoing:
Analysis of growth factor signaling networks and related gene expression profiles in liver, using a combination of computational modeling and experimental studies;
Signaling events associated with the onset and progression of liver regeneration, with emphasis on the control of energy metabolism, purinergic signaling and AMP-activated protein kinase;
Mechanisms of ethanol-associated disturbance of cellular Ca2+ homeostasis and Ca2+ signaling and its role in adaptation and stress-responses in the liver;
Mechanisms of ethanol-induced suscpetibility to apoptotic signals in the liver.
|Alcohol; ethanol; cellular signaling; calcium; growth factors; growth factor receptor; epidermal growth factor; receptor tyrosine kinase; mitogen activated protein kinase cascades; computational modeling; liver regeneration; energy metabolism; mitochondria; AMP-activated protein kinase; laboratory rat; partial hepatectomy; isolated hepatocytes; tissue cell culture; fluorescence microscopy.|
Last Updated by Jennifer Morris: Tuesday, September 28, 2010 5:07:46 PM