Faculty Affairs: Faculty Interests Database
Jack W. London

Cancer Biology
Thomas Jefferson University
Kimmel Cancer Center
KCC Shared Computer Facility
Director

Thomas Jefferson University
Jefferson Medical College
Kimmel Cancer Center
Research Associate Professor

Mailing Address Contact Information
808 BLSB, 233 S. 10th St.
Philadelphia, Pennsylvania 19107
United States
Phone: 215-503-4599
Fax: 215-955-9093
jack.london@KimmelCancerCenter.org
Personal Web Site
Qualifications
B.S., University of Pennsylvania, Engineering, 1967
Ph.D., University of California, Berkeley, Engineering, 1972

Expertise and Research Interests
Application of Informatics to Cancer Research

Dr. London's medical informatics research efforts are focused o­n the application of computer technology to cancer-related basic science and cancer clinical trials research. To facilitate basic science research at KCC, Dr. London's work involves the development of intranet-based translational research data acquisition. The intranet is used to acquire research data from multiple laboratories and clinical departments associated with program projects. The goal is to facilitate data entry, while providing secure access to all the laboratories' data for comprehensive analysis and review, including biostatistical analysis.

Development also continues o­n a repository of available tissue specimens for biomarker research with researchers from other NCI-designated cancer center members of the Pennsylvania Cancer Alliance. This project utilizes web-based databases for the acquisition and display of available biospecimens.

Dr. London represents the KCC for the NCI's Cancer Biomedical Informatics Grid (caBIG) initiative, which is building a national grid connecting individuals and institutions to enable the sharing of data and tools, creating a World Wide Web of cancer research. KCC is a funded developer for the Integrated Cancer Research (ICR) workspace, and a funded adopter in the Pathology and Tumor Bank Tools (TBPT) workspace. The ICR workspace project involves the adoption and modification of the NCI Center for Bioinformatics' (NCICB) microarray data portal, caARRAY. Dr. London's group is modifying the portal so that it can be integrated into the workflow normally found in cancer centers. The TBPT workspace project centers o­n the adoption of the caTISSUE CORE software application for biospecimen banking, and its integration into the informatics infrastructure at KCC. KCC is also a funded adopter in another TBPT project, the cancer Text Information Extraction System (caTIES). This project involves the automatic extraction of text from surgical pathology reports and the de-identification of the information for HIPAA compliance. When completed, caTIES will provide automated annotation for tissue bank databases with information found in surgical pathology reports. Dr. London also is a funded participant in the caBIG Data Sharing and Intellectual Capital work group, which is setting policy for the complex data sharing and intellectual capital issues involved in the establishment of a national research grid.

Dr. London's involvement in clinical research encompasses the development of computer systems for clinical trials, IRB, and Data Safety Monitoring (human subjects protection). An application to automate the calculations involved in patient chemotherapy regimens was developed by Dr. London's group, and is deployed at Thomas Jefferson University Hospital.
Keywords
Medical Informatics; Bioinformatics;
Publications
  • London J.W., Housman D., Sagenich C., Chatterjee D., Jatkar T., Isikoff J.M., Palchuk M.B. Integration of Research Biospecimen Annotation with Clinical Data in an i2b2 Research Data Mart. American Medical Informatics Association Annual Symposium, Washington, DC, November 2010.
  • London J.W., Smalley KJ, Chatterjee D., Isikoff J.M., Housman D., Palchuk M.B. Integration of caTissue with Clinical Data in an i2b2 Research Data Mart, Cancer Biomedical Informatics Grid (caBIG) Annual Meeting, Washington DC, September 2010.
  • London J.W. and Chatterjee D. Using the semantically interoperable biospecimen repository application, caTissue: End user deployment lessons learned. 10th International IEEE Conference on Bioinformatics and Bioengineering. Philadelphia June 2010.
  • London J.W., Smalley K.S., Conner K., and Smith J.B. The Automation of Clinical Trial Serious Adverse Event Reporting Workflow. Clinical Trials 6:446-454. (2009).
  • London J.W. Issues Relating to the Secondary Use of Clinical Data for Research. IEEE International
  • Conference on Bioinformatics & Biomedicine. Washington D.C. November 2009.
  • Patel AA, Gilbertson JR, Showe LC, London JW, Ross E, Ochs MF, Carver J, Lazarus A, Parwani AV, Dhir R, Beck JR, Liebman M, Garcia FU, Prichard J, Wilkerson M, Herberman RB, Becich MJ, and the PCABC: A Novel Cross-Disciplinary Multi-Institute Approach to Translational Cancer Research: Lessons Learned from Pennsylvania Cancer Alliance Bioinformatics Consortium (PCABC). Cancer Informatics 3:255-274 (2007).
  • Li F., Smalley K., and London J.W.: Adapting caArray to a Cancer Center's Workflow, NCI caBIG Annual Meeting, Washington, DC. April 2005.
  • London J.W. , Mervis S., and Kalf, G.F.: Tools for thePerformance of Clinical Trials Research, 11th World Congress o­n MedicalInformatics, San Francisco 2004.
  • R. Brandell-Marino, A. M. Valorie, C. Senholzi, J. London, and J.Filicko, Web Based Chemotherapy Ordering, American Society ofHealth-System Pharmacists 38th Midyear Clinical Meeting, New Orleams,2003.
  • London J.W. and Mervis S.: Cancer Clinical Trials Treatment Management Application, 10th World Congress on Health and Medical Informatics, London 2001.
  • Monzon F., London, J. W., and Palazzo J. P. Development of Web-Based Support Tools for a Comprehensive Breast Cancer Tissue and Data Procurement Program. (abstract) Modern Pathology 14:1, 234A (2001).
  • London, J. W. and Gomella L. G. Overview of the Internet and Prostate Cancer Resources, Seminars in Urologic Oncology 18:3, 245-253 (2000).
  • London J.W.: Oncology on the Internet, National Medical Association Annual Meeting, Washington, DC, 2000.
  • London J. W.: Lay Public Use of Healthcare Web Sites. In The Handbook of Healthcare Information Systems, P. L. Davidson, ed., CRC Press, Boca Raton, 2000, pp. 495-506.
  • London J.W.: Web-based protocol patient treatment scheduling, National Cancer Institute Technology Expo, American Medical Informatics Association Annual Symposium, Washington, DC, 1999.
  • London J.W.: Oncology on the Internet, National Medical Association Annual Meeting, Las Vegas, 1999.
  • London J.W.: Intranet Databases for Clinical Trials and Translational Research, Cancer Center Administrators Forum, Nashville, 1998.
  • London, J.W., Morton, D.E., Marinucci, D., Catalano, R. and Comis, R.L.: The implementation of telemedicine within a community cancer network. J. Am. Med. Informatics Assoc. 4: 18-24, 1997.
  • London J.W., Morton D.E., Marinucci D., Catalano R., and Comis R.L.: Telemedicine case study: Using desktop personal video conferencing for consultations between physicians in a community cancer network, Toward An Electronic Patient Record '97, Nashville, 1997.
  • London, J. W., Morton D.E., Marinucci D., Catalano R., and Comis R.L.: The Utilization of the World Wide Web and Telemedicine to Increase Participation in Cancer Clinical Research, Computers in Healthcare Education Symposium, Philadelphia, 1997.
  • London J.W.: Telemedicine case study: Using desktop personal video conferencing for consultations between physicians in a community cancer network, Disease Management Congress, Phoenix, 1997.
  • London J. W., Morton D.E., Marinucci D., Catalano R., and Comis, R.L., Strategies for PC/ISDN-based Telemedicine Consultations. In Proceedings of the 10th International Symposium on Computer Assisted Radiology, Paris 1996, H.U. Lemke, M.W. Vannier, K. Inamura, and A.G. Farman (eds.), pp 585-590.
  • London, J. W., Morton D.E., Marinucci D., Catalano R., and Comis R.L.: The Implementation of Telemedicine Within a Community Cancer Network, American Medical Informatics Association Spring Congress, Kansas City, 1996.
  • London, J. W., Morton D.E., Marinucci D., Catalano R., and Comis R.L.: Cost Effective Internet Access and Video Conferencing for a Community Cancer Network. In Proceedings of the Nineteenth Annual Symposium on Computer Applications in Medical Care, New Orleans, 1995, R. M. Gardner (ed.), pp 781-784.
  • London J. W., Morton D.E., Comis, R.L., Low-Cost Image Consultation Workstations Utilizing ISDN and Personal Computers. In Proceedings of the 9th International Symposium on Computer Assisted Radiology, Berlin 1995, H.U. Lemke, C.C. Jaffe, and M.W. Vannier (eds.), pp 759-764.
COS Profile
http://myprofile.cos.com/jwlondon

Last Updated by Jack London: Wednesday, April 6, 2011 1:43:48 PM

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