- Selected Publications (2000-present)
- Mundell, S. J. and Benovic, J. L. Selective regulation of endogenous G protein-coupled receptors by arrestins in HEK293 cells. J. Biol. Chem. 275:12900-12908, 2000.
- Santini, F., Penn, R.B., Gagnon, A.W., Benovic, J.L., and Keen, J.H. Selective recruitment of arrestin-3 to clathrin coated pits upon stimulation of G protein-coupled receptors. J. Cell Science 113:2463-70, 2000.
- Carman, C. V., Barak, L. S., Chen, C., Liu-Chen, L.-Y., Onorato, J. J., Kennedy, S. P., Caron, M. G., and Benovic, J. L. Mutational analysis of G-beta/gamma and phospholipid interaction with G protein-coupled receptor kinase 2. J. Biol. Chem. 275: 10443-10452, 2000.
- Mundell, S.J., Matharu, A.-L., Kelly, E., and Benovic, J.L. Arrestin isoforms dictate differential kinetics of A2B adenosine receptor trafficking. Biochemistry 39:12828-12836, 2000.
- Parent, J.-L., Labrecque, P., and Benovic, J. L. Role of the differentially spliced carboxyl-terminus in thromboxane A2 receptor trafficking: Identification of a distinct motif for tonic internalization. J. Biol. Chem. 276: 7079-7085, 2001.
- Penn, R. B., Pascual, R. M., Kim, Y.-M., Mundell, S. J., Krymskaya, V.P., Panettieri, R. and Benovic, J. L. Arrestin specificity for GPCRs in human airway smooth muscle. J. Biol. Chem. 276: 32648-32656, 2001.
- Marchese, A. and Benovic, J. L. Agonist-promoted ubiquitination of the G-protein-coupled receptor CXCR4 mediates lysosomal sorting. J Biol Chem. 276: 45509-45512, 2001.
- Milano, S.K., Pace, H.C., Kim, Y.-M., Brenner, C., and Benovic, J.L. Scaffolding functions of arrestin-2 revealed by crystal structure and mutagenesis. Biochemistry 41: 3321-3328, 2002.
- Gurevich, E.V., Benovic, J.L., and Gurevich, V.V. Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development. Neuroscience 109: 421-436, 2002.
- Kim, Y.M., Barak, L.S., Caron, M.G., and Benovic, J.L. Regulation of arrestin-3 phosphorylation by casein kinase II. J. Biol. Chem. 277: 16837-16846, 2002.
- Pao, C. and Benovic, J. Phosphorylation-independent desensitization of G protein-coupled receptors? Science's STKE (2002), http://stke.sciencemag.org/cgi/content/full/sigtrans;2002/ 153/pe42
- Bhattacharya, M., Anborgh, P. H., Babwah, A. V., Dale, L. B., Dobransky, T., Benovic, J. L., Feldman, R.D., Verdi, J. M., Rylett, R.J., and Ferguson, S.S.G. beta-Arrestins regulate a Ral-GDS-Ral effector pathway that mediates cytoskeletal reorganization. Nat. Cell Biol. 4: 547-555, 2002.
- Kim, Y.M. and Benovic, J. L. Differential roles of arrestin-2 interaction with clathrin and AP2 in G protein-coupled receptor trafficking. J. Biol. Chem. J. Biol. Chem. 277: 30760-30768, 2002.
- DeGraff, J.L., Gurevich, V.V., and Benovic, J.L. The third intracellular loop of alpha-2-adrenergic receptors determines subtype specificity of arrestin interaction. J. Biol. Chem. 277: 43247-43252, 2002.
- Marchese, A., Chen, C., Kim, Y.-M., and Benovic, J.L. The ins and outs of G protein-coupled receptor trafficking. Trends Biochem. Sci. 28: 369-376, 2003.
- Marchese, A., Raiborg, C., Santini, F., Keen, J.H., Stenmark, H., and Benovic, J.L. The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Developmental Cell 5: 709-722, 2003.
- Noble, B., Kallal, L.A., Pausch, M.H., and Benovic, J.L. Development of a yeast bioassay to characterize G protein-coupled receptor kinases: Identification of an N-terminal region essential for receptor phosphorylation. J. Biol. Chem. 278: 47466-47476, 2003.
- Luo, J., and Benovic, J.L. G protein-coupled receptor kinase interaction with Hsp90 mediates kinase maturation. J. Biol. Chem. 278: 50908-50914, 2003.
- Vishnivetskiy, S.A., Hosey, M.M., Benovic, J.L., and Gurevich, V.V. Mapping the arrestin-receptor interface: Structural elements responsible for receptor specificity of arrestin proteins. J. Biol. Chem. 279: 1262-1268, 2004.
- Gurevich, E.V., Benovic, J.L., and Gurevich, V.V. Arrestin2 expression selectively increases during neural differentiation. J. Neurochem. 91: 1404-1416, 2004.
- Day, P.W., Tesmer, J.J.G., Sterne-Marr, R., Freeman, L.C., Benovic, J.L., and Wedegaertner, P.B. Characterization of the GRK2 binding site of G-alpha-q. J. Biol. Chem. 279: 53643-53652, 2004.
- Iwata, K., Luo, J., Penn, R.B., and Benovic, J.L. Bimodal regulation of the human H1 histamine receptor by GRK2. J. Biol. Chem. 280: 2197-2204, 2005.
- Hardy, A.R., Conley, P.B., Luo, J., Benovic, J.L., Poole, A.W., and Mundell, S.J. P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms. Blood 105: 3552-3560, 2005.
- Naik, S., Billington, C.K., Pascual, R.M., Deshpande, D.A., Stefano, F.P., Kohout, T.A., Eckman, D.M., Benovic, J.L., and Penn, R.B. Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling. J. Biol. Chem. 280: 8722-8732, 2005.
- Pao, C.S. and Benovic, J.L. Structure/function analysis of alpha-2A-adrenergic receptor interaction with G protein-coupled receptor kinase 2. J. Biol. Chem. 280: 11052-11058, 2005.
- Palmitessa, A., Hess, H.A., Bany, I.A., Kim, Y.-M., Koelle, M.R., and Benovic, J.L. C. elegans arrestin regulates neural G protein signaling and olfactory adaptation and recovery. J. Biol. Chem. 280: 24649-24662, 2005.
- Milano, S.K., Kim, Y.-M., Stefano, F., Benovic, J.L. and Brenner, C. Phosphoinositide-dependent regulation of arrestin oligomerization and function. J. Biol. Chem. 281: 9812-9823, 2006.
- Lodowski, D.T., Tesmer, V.M., Benovic, J.L., and Tesmer, J.J.G. Crystal structure of G protein-coupled receptor kinase 6 defines the conserved molecular features of the GRK family. J. Biol. Chem. 281:16785-16793, 2006.
- Mundell, S.J., Luo, J., Benovic, J.L., Conley, P.B., and Poole, A.W. Distinct Clathrin-Coated Pits Sort Different G Protein-Coupled Receptor Cargo. Traffic 7: 1420-1431, 2006.
- Parameswaran, N., Pao, C.S., Leonhard, K.S., Kang, D.S., Kratz, M., Ley, S.C., and Benovic, J.L. Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappa B1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages. J. Biol. Chem. 281: 34159-34170, 2006.
- Jiang, X., Benovic, J.L, Wedegaertner, P.B. Plasma membrane and nuclear localization of G protein-coupled receptor kinase 6A. Mol. Biol. Cell 18: 2960-2969, 2007.
- Bhandari, D., Trejo, J., Benovic, J.L., and Marchese, A. Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase Atrophin-Interacting Protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. J. Biol. Chem. 282: 36971-36979, 2007.
- Moore, C.A.C., Milano, S.K., and Benovic, J.L. Regulation of receptor trafficking by GRKs and arrestins. Annu. Rev. Physiol. 69, 451-482, 2007.
- Busillo, J.M., and Benovic, J.L. Regulation of CXCR4 signaling. Biochim Biophys Acta. 1768: 952-963, 2007.
- Ahmed, M.A., Bychkov, E., Gurevich, V.V., Benovic, J.L., and Gurevich, E.V. Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by L-DOPA treatment. J. Neurochem. 104: 1622-1636, 2008.
- Ahmed, M.R., Gurevich, V.V., Dalby, K.N., Benovic, J.L., and Gurevich, E. Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and ERK activation. J. Pharmacol. Exp. Ther. 325: 276-283, 2008.
- Penn, R.B., and Benovic, J.L Regulation of heterotrimeric G-protein signaling in airway smooth muscle. Proc. Am. Thorac. Soc. 5: 47-57, 2008.
- Luo, J., Busillo, J.M., and Benovic, J.L. M3 muscarinic acetylcholine receptor-mediated signaling is regulated by distinct mechanisms. Mol. Pharm. 74: 338-347, 2008.
- Yang, M., He, R.L., Benovic, J.L., and Ye, R.D. beta-arrestin1 interacts with the G protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signaling for NF-kB activation. Biochem. J. 17: 287-296, 2009.
- Lakshmikanthan, V., Zou, L., Michal, A., Kim, J.I., Benovic, J.L., and Daaka, Y. Identification of beta-arrestin2 as a corepressor of androgen receptor signaling in prostate cancer. Proc. Natl. Acad. Sci. USA 106: 9379-9384, 2009.
- Zhu, C., Huang, H., Hua, R., Li, G., Yang, D., Luo, J., Zhang, C., Shi, L., Benovic, J.L., and Zhou, N. Molecular and functional characterization of adipokinetic hormone receptor and its peptide ligands in Bombyx mori. FEBS Lett. 583: 1463-1468, 2009.
- Kern, R.C., Kang, D.S., and Benovic, J.L. Arrestin2/clathrin interaction is regulated by key N- and C-terminal regions in arrestin2. Biochemistry 48: 7190-7200, 2009.
- Pao, C.S., Barker, B., and Benovic, J.L. Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation. Biochemistry 48: 7325-7333, 2009.
- Barthet, G., Carrat, G., Cassier, E., Barker, B., Gaven, F., Pillot, M., Framery, B., Pellissier, L.P., Augier, J., Kang, D.S., Claeysen, S., Reiter, E., Banères, J.L., Benovic, J.L., Marin, P., Bockaert, J., and Dumuis, A. beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT(4) receptor signalling. EMBO J. 28: 2706-2718, 2009.
- Kang D.S., Kern, R.C., Puthenveedu, M.A., von Zastrow, M., Williams, J.C., and Benovic, J.L. Structure of an arrestin-2/clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking. J. Biol. Chem. 284: 29860-29872, 2009.
- Patial, S., Luo, J., Porter, K.J., Benovic, J.L., and Parameswaran, N. G-protein coupled receptor kinases mediate TNFalpha-induced NFkappB signaling via direct interaction with and phosphorylation of IkBalpha. Biochem. J. 425: 169-178, 2010.
- Busillo, J.M., Armando, S., Sengupta, R., Meucci, O., Bouvier, M., and Benovic, J.L. Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J. Biol. Chem. 285: 7805-7817, 2010.
- Shankar, H. Michal, A., Kern, R.C., Kang, D.S., Gurevich, V.V., and Benovic, J.L. Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function. J. Biol. Chem. 285: 8316-8329, 2010.
- Mundell, S., Matharu, A.L., Nisar, S., Palmer, T., Benovic, J., and Kelly, E. Deletion of the distal COOH-terminus of the A2B adenosine receptor switches internalization to an arrestin- and clathrin-independent pathway and inhibits recycling. Br. J. Pharmacol. 159: 518-533, 2010.
- Palmitessa, A. and Benovic, J.L. Arrestin and the multi-PDZ domain containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate C. elegans longevity. J. Biol. Chem. 285: 15187-15200, 2010.
- Li, G., Shi, Y., Zhang, Y., Wu, K., Luo, J., Sun, Y., Lu, J., Benovic, J.L., and Zhou, N. Internalisation of the human nicotinic acid receptor GPR109A is regulated by Gi, GRK2 and arrestin3. J. Biol. Chem. 285: 22605-22618, 2010.
- Sosa, M.S., Lopez-Haber, C., Yang, C., Wang, H., Lemmon, M.A., Busillo, J.M., Luo, J., Benovic, J.L., Klein-Szanto, A., Yagi, H., Gutkind, J.S., Parsons, R.E., and Kazanietz, M.G. Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol. Cell 40: 877-879, 2010.
- Chen, X., Mei, L., Yan, J., Fan, Y., Yang, W., Luo, J., Hong, K., Wang, Z., Chen, X., Lu, J., Benovic, J.L., and Zhou, N. Structural determinants in the second intracellular loop of the human cannabinoid CB1 receptor mediate selective coupling to Gs and Gi. Br. J. Pharmacol. 161: 1817-1834, 2010.
- Huang, H., He, X., Deng, X., Li, G., Ying, G., Sun, Y., Shi, L., Benovic, J.L., and Zhou, N. Bombyx adipokinetic hormone receptor activates extracellular signal-regulated kinase 1 and 2 via G protein-dependent PKA and PKC but beta-arrestin-independent pathways. Biochemistry 49: 10862-10872, 2010.
- Michal, A.M., Tran, T.H., Ryder, A., Liu, C., Rimm, D.L., Rui, H., and Benovic, J.L. Differential expression of arrestins is a predictor of breast cancer progression and survival. Breast Cancer Res Treat, in press.
- Barker, B.L., and Benovic, J. L. G protein-coupled receptor kinase 5 phosphorylation of Hip regulates internalization of the chemokine receptor CXCR4. Biochemistry 50: 6933-6941, 2011.
- Bychkov, E.R., Ahmed, M.R., Gurevich, V.V., Benovic, J.L., and Gurevich E.V. Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder. Neurobiol. Dis., in press.
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