Faculty Interests Database

Faculty Affairs: Faculty Interests Database Hushan Yang, PhD

Medical Oncology
Assistant Professor
Division of Population Science
Department of Medical Oncology
Kimmel Cancer Center
Jefferson Medical College
Thomas Jefferson University

Mailing Address Contact Information
1025 Walnut Street, Room 1015
Philadelphia, Pennsylvania 19107
United States
Phone: 215-503-6521
Fax: 215-503-9506
PhD: Baylor College of Medicine, Houston, TX
Postdoc: University of Texas M.D. Anderson Cancer Center, Houston, TX
Expertise and Research Interests
Molecular cancer epidemiology, cancer pharmacogenetics, individualized cancer risk assessment and prognostication.
  • Rothman N et al. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet. 2010 Nov;42(11):978-84.
  • Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X. MicroRNA-related Genetic Variations as Predictors for Risk of Second Primary Tumor and/or Recurrence in Patients with Early-Stage Head and Neck Cancer. Carcinogenesis. 2010 [Epub ahead of print]
  • Chen M, Yang H, Wu X. Genetic Variations in the Sonic Hedgehog Pathway Affect Clinical Outcomes in Non-muscle-invasive Bladder Cancer. Cancer Prev Res (Phila Pa). 2010 Oct;3(10):1235-45.
  • Wang J, Lippman SM, Lee JJ, Yang H, Khuri FR, Kim E, Lin J, Chang DW, Lotan R, Hong WK, Wu X. Genetic Variations in Regulator of G-Protein Signaling Genes as Susceptibility Loci for Second Primary Tumor/Recurrence in Head and Neck Squamous Cell Carcinoma. Carcinogenesis. 2010 Oct;31(10):1755-61.
  • Chen M, Cassidy A, Gu J, Delclos GL, Zhen F, Yang H, Hildebrandt MA, Lin J, Ye Y, Chamberlain RM, Dinney CP, Wu X. Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk. Carcinogenesis. 2009 Dec;30(12):2047-52.
  • Clague J, Lippman SM, Yang H, Hildebrandt MA, Ye Y, Lee JJ, Wu X. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. Mol Carcinog. 2009 Oct 22.
  • Yang H, Gu J, Wang KK, Zhang W, Xing J, Chen Z, Ajani JA, Wu X. MicroRNA expression signatures in Barrett's esophagus and esophageal adenocarcinoma. Clin Cancer Res. 2009 Sep 15;15(18):5744-52.
  • Chen M, Ye Y, Yang H, Tamboli P, Matin S, Tannir NM, Wood CG, Gu J, Wu X. Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays. Int J Cancer. 2009 Nov 15;125(10):2342-8.
  • Wu X, Spitz MR, Lee JJ, Lippman SM, Ye Y, Yang H, Khuri FR, Kim E, Gu J, Lotan R, Hong WK. Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants. Cancer Prev Res (Phila Pa). 2009 Jul;2(7):617-24.
  • Gou X, Ru Q, Zhang H, Chen Y, Li L, Yang H, Xing J, Chen Z. HAb18G/CD147 inhibits starvation-induced autophagy in human hepatoma cell by down-regulating Beclin 1 expression. Cancer Science. 2009 May;100(5):837-43.
  • Pu X, Lippman SM, Yang H, Lee JJ, Wu X. Functional polymorphisms of COX-2 gene and risk of oral premalignant lesions. Cancer 2009 Apr 1;115(7):1498-506.
  • Hildebrandt MA, Yang H, Hung M, Izzo J, Huang M, Lin J, Ajani JA, Wu X. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes following chemoradiation for patients with esophageal cancer. J Clin Oncol 2009 Feb 20;27(6):857-71.
  • Horikawa Y, Wood CG, Yang H, Zhao H, Ye Y, Gu J, Habuchi T, Wu X. Single nucleotide polymorphisms of microRNA-machinery genes modify the risk of renal cell carcinoma. Clin Cancer Res 2008 Dec; 14(23):7956-62.
  • Wu X, Lu C, Ye Y, Chang J, Yang H, Lin J, Gu J, Hong WK, Stewart DJ, Spitz MR. Genetic polymorphisms predict clinical outcomes in advanced NSCLC patients receiving chemotherapy. Pharmacogenet Genomics 2008 Nov 18(11):955-65.
  • Ye Y, Wang K, Gu J, Yang H, Lin J, Ajani JA, Wu X. Genetic variations in microRNA-related genes as novel susceptibility loci for esophageal cancer risk. Cancer Prev Res 2008 Nov 1(6):460-69.
  • Margulis V, Lin J, Yang H, Wood CG, Wu X. Genetic susceptibility to renal cell carcinoma: the role of DNA double strand break repair pathway. Cancer Epidemiol Biomarkers Prev 2008 Sep: 7(9):2445-50.
  • Yang H, Lippman SM, Huang M, Lee JJ, Wang W, Spitz MR, Wu X. Genetic polymorphisms in double-strand DNA repair genes are associated with risk of oral premalignant lesions. Eur J Cancer 2008 Jul; 44(11):1603-11.
  • Ye Y, Yang H, Dinney CP, Spitz MR, Wu X. Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer. Cancer 2008 June 1; 112 (11): 2467-74.
  • Zhu Y, Horikawa Y, Yang H, Wood CG, Habuchi T, Wu X. BPDE-induced lymphocytic chromosome 3p deletions may predict renal cell carcinoma risk. Journal of Urology 2008 Apr 21; 179(6): 2416-21.
  • Yang H, Gu J, Lin X, Grossman HB, Ye Y, Dinney CP, Wu X. Profiling of genetic variations in inflammation pathway genes in relationship to bladder cancer predisposition. Clin Cancer Res 2008 Apr 1; 14(7): 2236-44.
  • Yang H, Dinney CP, Ye Y, Zhu Y, Grossman HB, Wu X. Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. Cancer Res 2008 Apr 1; 68(7):2530-7.
  • Zhu Y, Yang H, Chen Q, Lin J, Grossman HB, Dinney CP, Wu X, Gu J. Modulation of DNA damage/DNA repair capacity by XPC polymorphisms. DNA Repair (Amst). 2008 Feb 1;7(2):141-8.
  • Milam M, Gu J, Yang H, Celestino J, Wu W, Horwitz I, Lacour R, Westin S, Gershenson D, Wu X, Lu K. STK15 F31I polymorphism is associated with increased uterine cancer risk: a pilot study. Gynecologic Oncology 2007 Oct;107(1):71-4.
  • Wang W, Spitz MR, Yang H, Lu C, Stewart DJ, Wu X. Genetic variants in cell cycle control pathway confer susceptibility to lung cancer. Clin Cancer Res 2007 Oct 1;13(19):5974-81.
  • Yang H, Spitz MR, Stewart DJ, Lu C, Gorlov IP, Wu X. ATM sequence variants associate with susceptibility to non-small cell lung cancer. Int J Cancer 2007 Nov 15;121(10):2254-9.
  • Lin X, Wood CG, Shao L, Huang M, Yang H, Dinney CP, Wu X. Risk assessment of renal cancer using alkaline comet assay. Cancer 2007 Jul 15;110(2):282-8.
  • Xing J, Spitz MR, Lu C, Zhao H, Yang H, Wang W, Stewart DJ, Wu X.. Deficient G2/M and S checkpoints are associated with increased lung cancer risk: A case-control analysis. Cancer Epidemiol Biomarkers Prev 2007 Jul;16(7):1517-22.
  • Xing J, Zhu Y, Zhao H, Yang H, Chen M, Spitz MR, Wu X. Differential induction in telomerase activity among bladder cancer patients and controls upon ³-radiation. Cancer Epidemiol Biomarkers Prev 2007 Mar;16(3):606-9.
  • Shao L, Hittelman WN, Lin J, Yang H, Ajani JA, Wu X. Deficiency of cell cycle checkpoints and DNA repair system predispose individuals to esophageal cancer. Mutat Res 2006 Dec 1;602(1-2):143-50.
  • Zhu Y, Lai M, Yang H, Lin J, Huang M, Grossman HB, Dinney CP, Wu X. Genotypes, haplotypes, and diplotypes of XPC and risk of bladder cancer. Carcinogenesis 2006 Mar;28(3):698-703.
  • Gonzeles B, Yang H, Henning D, Valdez BC. Cloning and functional characterization of the Xenopus orthologue of the Treacher Collins syndrome (TCOF1) gene product. Gene 2005 Oct 10;359:73-80.
  • Yang H, Henning D, Valdez BC. Functional interaction between RNA helicase II/Gua and ribosomal protein L4. FEBS J 2005 Aug 272;(15) 3788-802.
  • Yang H, Zhou J, Ochs RL, Henning D, Jin R, Valdez BC. Down-regulation of RNA helicase II/Gu results in the depletion of 18S and 28S rRNAs in Xenopus oocyte. J Biol Chem 2003 Oct 3;278(40):38847-59.
  • Valdez BC, Yang H, Hong E, Sequitin AM. Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs. Gene 2002 Feb 6;284(1-2):53-61.

Last Updated by Hushan Yang, PhD: Wednesday, November 10, 2010 5:05:26 PM

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