Faculty Affairs: Faculty Interests Database
Fabienne Paumet

Microbiology & Immunology
Mailing Address Contact Information
233 S 10th street Bluemle Building Rm750
Philadelphia, Pennsylvania 19107
United States
Phone: 215-503-8567
Fabienne.Paumet@jefferson.edu
Qualifications
2007-present: Assistant Professor, Thomas Jefferson University, Philadelphia, USA

2005-2007: Post-doctoral research associate , Columbia University, New York, USA

2000-2005: Post-doctoral fellow, Memorial Sloan-Kettering Cancer Center / Columbia University , New York, USA

1999: Ph.D., Pasteur Institute, Paris, France


Expertise and Research Interests
MOLECULAR MECHANISMS OF PHAGOCYTOSIS: HOW DO PATHOGENS SUBVERT THIS PROCESS?
*Unraveling membrane trafficking involved in the phagocytic pathway and its regulation
*How do intracellular bacteria interfere with the host phagocytic system to escape lysosomal degradation?

DO INTRACELLULAR BACTERIA COMMONLY USE SNARE-LIKE PROTEINS TO MANIPULATE THE HOST MEMBRANE FUSION?
*Screening Salmonella and Legionella genomes
*Study the inhibitory effect of potential SNARE-like bacterial proteins

CHARACTERIZATION OF EUKARYOTIC MEMBRANE FUSION MACHINERY
*Identification and characterization of primitive membrane fusion machineries (similar to SNARE proteins)
*Characterization of the specificity of fusion encoded in the SNARE proteins
*Characterization of intramolecular SNARE regulation

STUDY OF THE PHAGOCYTIC MECHANISM IN MAST CELLS, ONE OF THE MAIN PLAYERS IN ALLERGY
Keywords
Membrane fusion, SNARE protein, Phagocytosis, Endocytosis, Exocytosis, Vesicular trafficking, Intracellular bacteria, Bacterial SNARE-like protein, SNARE evolution, Mast cell, Degranulation, Salmonella, Chlamydia, Legionella, E. coli
Languages
French, English
Publications
  • J. Wesolowski, F. Paumet SNARE motif: a common motif used by pathogens to manipulate membrane fusion, Virulence (2010) 1: 319-324
  • F. Paumet*, J. Wesolowski, A. Garcia-Diaz, C. Delevoye, N. Aulner, H.A. Shuman, A. Subtil, J.E. Rothman Intracellular bacteria encode inhibitory SNARE-like proteins, PLoS One (2009) 4:e7375 (*corresponding author)
  • C. Delevoye, M. Nilges, P. Dehoux, F. Paumet, S. Perrinet, A. Dautry-Varsat, A. Subtil SNARE protein mimicry by an intracellular bacterium PLOS Pathogens (2008) 4:e1000022
  • J. Shen, D. Tareste, F. Paumet, JE. Rothman, T.J. Melia Selective activation of cognate SNAREpins by Sec1/Munc18 (SM) proteins Cell (2007) 128: 183-195
  • D. Dao*, C. Dobbs*, A. Goldrath*, MJ. Khoury*, C. Lengsfeld*, A. McBride*, C. McCarty*, F. Paumet*, JE. Wiktorowicz*, Z. Yang* (*Alphabetic order) The Genomic Revolution - Implications for Treatment and Control of Infectious Disease: Can genomics facilitate vaccine development? Keck Futures Initiatives- The National Academies Press, Washington D.C. (2006) p33-9.
  • F. Paumet, V. Rahimian, M. DiLiberto, JE. Rothman Concerted auto-regulation in yeast endosomal t-SNAREs Journal of Biological Chemistry (2005) 280: 21137-43
  • F. Paumet, V. Rahimian, JE. Rothman The specificity of SNARE-dependent fusion is encoded in the SNARE motif PNAS (2004) 101:3376-80
  • O. Varlamov, A. Volchuk, V. Rahimian, CA. Doege, F. Paumet, WS. Eng, N. Arango, F. Parlati, M. Ravazzola, L. Orci, TH. Söllner and JE. Rothman i-SNAREs, inhibitory SNAREs that fine-tune the specificity of membrane fusion, Journal of Cell Biology (2004) 164:79-88.
  • F. Paumet, La fusion cellulaire, Médecine/Science, (2003) 6-7:663-4
  • T. Galli and F. Paumet, Exocytosis and endocytosis in neurons In: The Encyclopedia of Neuroscience, 3rd Ed. (Web). (2003) Adelman G, Smith BH, Editors. Amsterdam/New York: Elsevier Science.
  • *T. Galli and F. Paumet, Du trafic dans les neurones, Pour la Science, (2002) 302: 66-73
  • T. Galli, S. Martinez-Arca, F. Paumet Mécanisme de la fusion membranaire, Médecine/Science, (2002) 18:1113-9
  • U. Blank, B. Cyprien, S. Martin-Verdeaux, F. Paumet, I. Pombo, J. Rivera, M. Roa and N. Varin-Blank SNAREs and associated regulators in the control of exocytosis in the RBL-2H3 mast cell line, Molecular Immunology, (2002) 1156: 1-5
  • F. Paumet, B. Brügger, F. Parlati, JA. McNew, TH. Söllner, JE. Rothman "A t-SNARE of the endocytic pathway must be activated for fusion", Journal of Cell Biology, (2001) 155: 961-8
  • JA. McNew, F. Parlati, R. Fukuda, RJ. Johnston, K. Paz, F. Paumet, TH. Söllner, JE. Rothman "Compartmental specificity of cellular membrane fusion encoded in SNARE proteins", Nature, (2000) 407: 153-9
  • F. Paumet, J. Le Mao, S. Martin, T. Galli, B. David, U. Blank, M. Roa, "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: Functional role of Syntaxin4 in exocytosis and identification of a VAMP8-containing secretory compartment" Journal of Immunology, (2000) 164: 5850-7
  • M. Roa*, F. Paumet*, J. Le Mao, B. David, U. Blank (* co-first authorship), "Involvement of the ras-like GTPase rab3d in RBL-2H3 mast cell exocytosis following stimulation via high affinity IgE receptors (FcµRI)", Journal of Immunology, (1997) 159: 2815-23

Last Updated by Fabienne Paumet: Wednesday, April 6, 2011 11:46:00 AM

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