Faculty Affairs: Faculty Interests Database
Benjamin E. Leiby

Pharmacology & Experimental Therapeutics
Thomas Jefferson University
Jefferson Medical College
Department of Pharmacology and Experimental Therapeutics
Division of Biostatistics
Assistant Professor
Appointed: 2006
Mailing Address Contact Information
1015 Chestnut St., Suite M100
Philadelphia, Pennsylvania 19107
United States
Phone: 215-503-3803
Fax: 215-503-3804
benjamin.leiby@jefferson.edu
Qualifications
Ph.D., University of Pennsylvania, Biostatistics, 2006
Expertise and Research Interests
My current projects include behavioral interventions for preventing depression and improving function in individuals with macular degeneration, biomarkers for prostate and pancreatic cancer, assessment of function in those with spinal cord injury, and various areas of ophthalmology. My statistical methods interests include latent class models, latent variable models, and longitudinal data analysis.
Keywords
Biostatistics; Psychiatry; Cancer Biology; Medical Oncology; OB/GYN; Ophthalmology; Rehabilitation Medicine
Publications
  • Selected Recent Publications
  • Rovner BW, Casten RJ, Leiby BE, Tasman WS. Activity loss is associated with cognitive decline in age-related macular degeneration. Alzheimers Dement. 2009 Jan;5(1):12-7. PMID: 19118805
  • Rovner, BW, Casten, RJ, Leiby, BE. Variability in Geriatric Depression Scale Scores Predicts CognitiveDecline in Age-Related Macular Degeneration. Am J Geriatric Psychiatry. 2009 Jul; 17(7):574-81. PMCID: PMC2704479
  • Leiby BE, Sammel MD, Ten Have TR, Lynch KG. Identification of Multivariate Responders/Non-Responders Using Bayesian Growth Curve Latent Class Models. Applied Statistics. 2009 58(4): 505-24. PMCID: PMC3104279
  • Andrel JA, Keith SW, Leiby BE. Meta-Analysis: a brief introduction. Clinical and Translational Science. 2009 2(5):374-8.
  • Casten, RJ, Rovner BW, Leiby BE, and the Wills Eye AMD Study Group. Depression despite Anti-VEGF Treatment of AMD. Arch Ophthal. 2010 Apr;128(4):506-8.
  • Gu L, Dagvadorj A, Lutz J, Leiby B, Bonuccelli G, Lisanti MP, Addya S, Fortina P, Dasgupta A, Hyslop T, Bubendorf L, Nevalainen MT. Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth. Am J Pathol. 2010 Apr:176(4):1959-72. PMCID: PMC2843484
  • Gu L, Vogiatzi P, Puhr M, Dagvadorj A, Lutz J, Ryder A, Addya S, Fortina P, Cooper C, Leiby B, Dasgupta A, Hyslop T, Bubendorf L, Alanen K, Mirtti T, Nevalainen M. Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo. Endocr Relat Cancer. 2010 18:481-93.
  • Rovner BW, Casten RJ, Hegel MT, Massof RW, Leiby BE, Tasman WS. Improving function in Age-Related Macular Degeneration: Design and methods of a randomized clinical trial. Contemp Clin Trials. 2011 Mar;32(2):196-203. PMCID: PMC3034775
  • Marino RJ, Burns S, Graves DE, Leiby BE, Kirshblum S, Lammertse DP. Upper- and lower-extremity motor recovery after traumatic cervical spinal cord injury: an update from the national spinal cord injury database. Arch Phys Med Rehabil. 2011 Mar;92(3):369-75.
  • Jindal AP, Fleischman D, Leiby B, Spaeth GL, Myers JS, Katz LJ. Effects of acutely lowering intraocular pressure on the results of multifocal visual evoked potential testing. Acta Ophthalmol. 2011 Nov; 89(7):e550-4.
  • Rovner BW, Casten RJ, Massof RW, Leiby BE, Tasman WS. Psychological and cognitive determinants of vision function in age-related macular degeneration. Arch Ophthalmol. 2011 Jul;129(7):885-90.
  • Casten RJ, Brawer R, Haller JA, Hark LA, Henderer J, Leiby B, Murchison AP, Plumb J, Rovner BW, Weiss DM. Trial of a behavioral intervention to increase dilated fundus examinations in African-Americans aged over 65 years with diabetes. Expert Rev Ophthalmol. 2011; 6(6), 593-601.
  • Patrick M, Ditunno P, Ditunno JF, Marino RJ, Scivoletto G, Lam T, Loffree J, Tamburella F, Leiby B. Consumer preference in ranking walking function utilizing the walking index for spinal cord injury II. Spinal Cord. 2011 Dec; 49(12):1164-72.
  • Williams AL, Gatla S, Leiby BE, Fahmy I, Biswas A, de Barros DM, Ramakrishnan R, Bhardwaj S, Wright C, Dubey S, Lynch JF, Bayer A, Khandelwal R, Ichhpujani P, Gheith M, Siam G, Feldman RM, Henderer JD, Spaeth GL. The Value of Intraocular Pressure Asymmetry in Diagnosing Glaucoma. J Glaucoma. 2011 Oct 24. [Epub ahead of print]
  • Rovner BW, Casten RJ, Hegel MT, Leiby BE. Preventing cognitive decline in older African Americans with mild cognitive impairment: Design and methods of a randomized clinical trial. Contemp Clin Trials. 2012 Mar 2. [Epub ahead of print]
  • Valsecchi ME, Holdbrook T, Leiby BE, Pequignot E, Littman SJ, Yeo CJ, Brody JR, Witkiewicz AK. Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma? BMC Cancer. 2012 Mar 22;12(1):104. [Epub ahead of print]
  • Marino RJ, Patrick M, Albright W, Leiby BE, Mulcahey M, Schmidt-Read M, Kern SB. Development of an Objective Test of Upper-Limb Function in Tetraplegia: The Capabilities of Upper Extremity Test. Am J Phys Med Rehabil. 2012 Mar 29. [Epub ahead of print]
  • Rovner BW, Casten RJ, Leiby BE. Cognitive and noncognitive determinants of everyday activities in a racially diverse population of older persons receiving health services. J Nerv Ment Dis. 2012 Jul;200(7): 627-31.
  • Pineda DM, Rittenhouse DW, Valley CC, Cozzitorto JA, Burkhart RA, Leiby B, Winter JM, Weber MC, Londin ER, Rigoutsos I, Yeo CJ, Gorospe M, Witkiewicz AK, Sachs JN, Brody JR. HuR's post-transcriptional regulation of Death Receptor 5 in pancreatic cancer cells. Cancer Biol Ther. 2012 Aug;13(10):946-55. Epub 2012 Aug 1.
  • Leiby BE, Ten Have TR, Lynch KG, Sammel MD. Bayesian multivariate growth curve latent class models for mixed outcomes. Stat Med. 2012 Sep 7. doi: 10.1002/sim.5596. [Epub ahead of print].
  • Mirtti T*, Leiby BE*, Abdulghani J, Aaltonen E, Pavela M, Mamtani A, Alanen K, Egevad L, Granfors T, Josefsson A, Stattin P, Bergh A, Nevalainen MT. Nuclear Stat5a/b predicts early recurrence and prostate cancer-specific death in patients treated by radical prostatectomy. Hum Pathol. 2012 Sep 28. doi:pii: S0046-8177(12)00207-9. 10.1016/j.humpath.2012.06.001. [Epub ahead of print] *Equal Contribution.
  • Leiby BE. Growth curve mixture models. Shanghai Archives of Psychiatry. 2012 Nov; 24(6) 355-8
  • Rovner BW, Casten RJ, Hegel MT, Massof RW, Leiby BE, Ho AC, Tasman WS. Improving Function in Age-Related Macular Degeneration: A Randomized Clinical Trial. Ophthalmology. 2013 May 1. [Epub ahead of print]
  • Haddad BR, Gu L, Mirtti T, Dagvadorj A, Vogiatzi P, Hoang DT, Bajaj R, Leiby B, Ellsworth E, Blackmon S, Ruiz C, Curtis M, Fortina P, Ertel A, Liu C, Rui H, Visakorpi T, Bubendorf L, Lallas CD, Trabulsi EJ, McCue P, Gomella L, Nevalainen MT. STAT5A/B Gene Locus Undergoes Amplification during Human Prostate Cancer Progression. Am J Pathol. 2013 Jun;182(6):2264-75.
  • Monti DA, Kash KM, Kunkel EJ, Moss A, Mathews M, Brainard G, Anne R, Leiby BE, Pequinot E, Newberg AB. Psychosocial benefits of a novel mindfulness intervention versus standard support in distressed women with breast cancer. Psychooncology. 2013 Jul 21. [Epub ahead of print]
  • Nevalainen MT, Gu L, Liao Z, Hoang DT, Dagvadorj A, Gupta S, Blackmon S, Ellsworth E, Talati P, Leiby B, Zinda M, Lallas CD, Trabulsi EJ, McCue PA, Gomella LG, Huszar D. Pharmacological inhibition of JAK2-STAT5 signaling by JAK2 inhibitor AZD1480 potently suppresses growth of both primary and castrate-resistant prostate cancer. Clin Cancer Res. 2013 Aug 13. [Epub ahead of print]
COS Profile
http://myprofile.cos.com/bleiby

Last Updated by Benjamin Leiby: Wednesday, December 2, 2009 2:35:18 PM

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