Faculty Affairs: Faculty Interests Database A. Sue Menko, PhD
Pathology, Anatomy & Cell Biology
Vice Chair, Anatomy
Director, Wills Vision Research Center at Jefferson
|Mailing Address||Contact Information|
1020 Locust Street JAH 564
Philadelphia, Pennsylvania 19107
Phone: (215) 503-2166
Fax: (215) 923-3808
|Ph.D., University of Pennsylvania, 1978
|Expertise and Research Interests|
|My laboratory studies how receptor-signaling pathways instruct an undifferentiated cell to obtain its differentiated phenotype and those signals responsible for organizing differentiating cells into a three-dimensional functional structure - a process in development know as morphogenesis. We address how these features of differentiation and morphogenesis apply to tissue regeneration. In addition, there is now a strong focus in our lab on the mechanisms of wound healing and fibrosis. These studies are focused the role of repair cells in directing normal wound healing and how this cell population can go astray and lead to disease states, particularly fibrosis, as in the post-cataract surgery disease PCO.
Specific projects include:
The role of the alpha6 integrin receptor as an upstream regulator of survival pathways that permit caspase-3, activated downstream of a classical mitochondrial death pathway, to function as a molecular switch in the initiation of differentiation.
How coordinate signaling between integrins and growth factor receptor signaling pathways provide specificity to integrin signaling during differentiation initiation.
The role of adhesion receptors in regulating the function of actin and intermediate filament cytoskeletons to drive morphogenesis during development.
Integrin-cadherin cross-talk in cell differentiation.
Mechanisms of wound healing - studies of a unique repair cell population that regulates wound healing of epithelia.
Studies of wound healing repair cells as the source of fibrotic disease.
|My laboratory is involved in developing therapeutics to block the induction of Posterior Capsule Opacification (PCO) and cataract. These studies are focused on targeting signaling pathways we have shown are involved in the development of these diseases.|
|Cadherin; Cataract Signaling Pathways; Cell Adhesion Molecules; Cell Differentiation; Cell-Cell Interaction; Cell-Matrix Interaction; Cytoskeleton; Development; Extracellular Matrix; Growth Factor Receptor; Integrin Receptor Signaling; Lens Differentiation; Protein Tyrosine Kinases; Signal Transduction; Signaling; Src Kinases|
Last Updated by Jennifer Morris: Thursday, January 5, 2012 9:51:24 AM