Faculty Interests Database

Faculty Affairs: Faculty Interests Database Adam E. Snook, PhD

Pharmacology & Experimental Therapeutics
Position information is not available.
Mailing Address Contact Information
1020 Locust Street, JAH 368E
Philadelphia, Pennsylvania 19107
United States
Phone: 215-503-7445
Fax: 215-955-7006
Personal Web Site
BS, University of the Sciences, Pharmacology and Toxicology, 2001
PhD, Thomas Jefferson University, Immunology and Microbial Pathogenesis, 2008
Guanylyl cyclases, intestinal epithelial cell biology, GI malignancies, colorectal cancer, targeted therapeutics, cancer mucosal antigens, cancer vaccines, immune tolerance, adoptive cell therapy
  • Snook, A. E., Blomain E.S., Aing, A. S., Merlino, D. and Waldman, S.A. (2016). Guanylyl Cyclase Receptors. Encyclopedia of Cell Biology. R. A. Bradshaw and P. D. Stahl. Waltham, Academic Press: 56-60.
  • Perepelyuk, M., Thangavel, C., Liu, Y., Den, R.B., Lu, B., Snook, A. E., and Shoyele, S. A. (2016). "Biodistribution and Pharmacokinetics Study of siRNA-loaded Anti-NTSR1-mAb functionalized Novel Hybrid Nanoparticles in a Metastatic Orthotopic Murine Lung Cancer Model." Mol Ther Nucleic Acids 5: e282.
  • Lin, J. E., Colon-Gonzalez, F., Blomain, E. S., Kim, G. W., Aing, A., Stoecker, B., Rock, J., Snook, A. E., Zhan, T., Hyslop, T. M., Tomczak, M., Blumberg, R. S., and Waldman, S. A. (2016). "Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin GUCY2C Paracrine Signaling Axis." Cancer Res 76(2): 339-346.
  • Snook, A. E., T. Baybutt, M. Mastrangelo, N. Lewis, S. Goldstein, W. Kraft, Y. Oppong, T. Hyslop, R. Myers, V. Alexeev, L. Eisenlohr, T. Sato and S. Waldman (2015). "A Phase I study of Ad5-GUCY2C-PADRE in stage I and II colon cancer patients." Journal for ImmunoTherapy of Cancer 3(Suppl 2): P450.
  • Krishnan, V., X. Xu, D. Kelly, A. Snook, S. A. Waldman, R. W. Mason, X. Jia and A. K. Rajasekaran (2015). "CD19-Targeted Nanodelivery of Doxorubicin Enhances Therapeutic Efficacy in B-Cell Acute Lymphoblastic Leukemia." Mol Pharm 12(6): 2101-2111.
  • Goodwin, J. F., V. Kothari, J. M. Drake, S. Zhao, E. Dylgjeri, J. L. Dean, M. J. Schiewer, C. McNair, J. K. Jones, A. Aytes, M. S. Magee, A. E. Snook, Z. Zhu, R. B. Den, R. C. Birbe, L. G. Gomella, N. A. Graham, A. A. Vashisht, J. A. Wohlschlegel, T. G. Graeber, R. J. Karnes, M. Takhar, E. Davicioni, S. A. Tomlins, C. Abate-Shen, N. Sharifi, O. N. Witte, F. Y. Feng and K. E. Knudsen (2015). "DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis." Cancer Cell 28(1): 97-113.
  • Snook, A. E., M. S. Magee, S. Schulz and S. A. Waldman (2014). "Selective antigen-specific CD4(+) T-cell, but not CD8(+) T- or B-cell, tolerance corrupts cancer immunotherapy." Eur J Immunol 44(7): 1956-1966.
  • Snook, A. E. (2014). "Could targeting T-helper cells aid the development of effective cancer vaccines?" Immunotherapy 6(9): 959-961.
  • Witek, M. E., A. E. Snook, J. E. Lin, E. S. Blomain, B. Xiang, M. Magee and S. A. Waldman (2014). "A novel CDX2 isoform regulates alternative splicing." PLoS One 9(8): e104293.
  • Witek, M., J. Siglin, T. Malatesta, A. Snook, E. Gressen, S. Rudoler, V. Bar-Ad and S. Fisher (2014). "Is Financial Literacy Necessary for Radiation Oncology Residents?" International Journal of Radiation Oncology*Biology*Physics 90(5): 986-987.
  • Witek, M., E. S. Blomain, M. S. Magee, B. Xiang, S. A. Waldman and A. E. Snook (2014). "Tumor radiation therapy creates therapeutic vaccine responses to the colorectal cancer antigen GUCY2C." Int J Radiat Oncol Biol Phys 88(5): 1188-1195.
  • Wilson, C., J. E. Lin, P. Li, A. E. Snook, J. Gong, T. Sato, C. Liu, M. A. Girondo, H. Rui, T. Hyslop and S. A. Waldman (2014). "The Paracrine Hormone for the GUCY2C Tumor Suppressor, Guanylin, Is Universally Lost in Colorectal Cancer." Cancer Epidemiol Biomarkers Prev 23(11): 2328-2337.
  • Marszalowicz, G. P., A. E. Snook, M. S. Magee, D. Merlino, L. D. Berman-Booty and S. A. Waldman (2014). "GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer." Oncotarget 5(19): 9460-9471.
  • Magee, M. S. and A. E. Snook (2014). "Challenges to chimeric antigen receptor (CAR)-T cell therapy for cancer." Discov Med 18(100): 265-271.
  • Hersperger, A. R., N. A. Siciliano, B. C. DeHaven, A. E. Snook and L. C. Eisenlohr (2014). "Epithelial immunization induces polyfunctional CD8+ T cells and optimal mousepox protection." J Virol 88(16): 9472-9475.
  • Hayes, C. S., A. C. Shicora, M. P. Keough, A. E. Snook, M. R. Burns and S. K. Gilmour (2014). "Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment." Cancer Immunol Res 2(3): 274-285.
  • Xiang, B., A. E. Snook, M. S. Magee and S. A. Waldman (2013). "Colorectal cancer immunotherapy." Discov Med 15(84): 301-308.
  • Snook, A. E. and S. A. Waldman (2013). "Advances in cancer immunotherapy." Discov Med 15(81): 120-125.
  • Magee, M. S., A. E. Snook and S. A. Waldman (2013). Adoptive Cell Therapy: At the Forefront of Cancer Immunotherapy. Horizons in Cancer Research. H. S. Watanabe. Hauppauge, NY, Nova Science Publishers, Inc. 51
  • Magee, M. S., A. E. Snook, G. P. Marszalowicz and S. A. Waldman (2013). "Immunotherapeutic strategies to target prognostic and predictive markers of cancer." Biomark Med 7(1): 23-35.
  • Gibbons, A. V., J. E. Lin, G. W. Kim, G. P. Marszalowicz, P. Li, B. A. Stoecker, E. S. Blomain, S. Rattan, A. E. Snook, S. Schulz and S. A. Waldman (2013). "Intestinal GUCY2C prevents TGF-beta secretion coordinating desmoplasia and hyperproliferation in colorectal cancer." Cancer Res 73(22): 6654-6666.
  • Blomain, E. S., J. E. Lin, C. L. Kraft, U. T. Trela, J. M. Rock, A. S. Aing, A. E. Snook and S. A. Waldman (2013). "Translating colorectal cancer prevention through the guanylyl cyclase C signaling axis." Expert Rev Clin Pharmacol 6(5): 557-564.
  • Snook, A. E., M. S. Magee, G. P. Marszalowicz, S. Schulz and S. A. Waldman (2012). "Epitope-targeted cytotoxic T cells mediate lineage-specific antitumor efficacy induced by the cancer mucosa antigen GUCY2C." Cancer Immunol Immunother 61(5): 713-723.
  • Lin, J. E., A. E. Snook, P. Li, B. A. Stoecker, G. W. Kim, M. S. Magee, A. V. Garcia, M. A. Valentino, T. Hyslop, S. Schulz and S. A. Waldman (2012). "GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity." PLoS One 7(2): e31686.
  • Valentino, M. A., J. E. Lin, A. E. Snook, P. Li, G. W. Kim, G. Marszalowicz, M. S. Magee, T. Hyslop, S. Schulz and S. A. Waldman (2011). "A uroguanylin-GUCY2C endocrine axis regulates feeding in mice." J Clin Invest 121(9): 3578-3588.
  • Snook, A. E., M. S. Magee and S. A. Waldman (2011). "GUCY2C-targeted cancer immunotherapy: past, present and future." Immunol Res 51(2-3): 161-169.
  • Magee, M. S., A. E. Snook, N. A. Siciliano and S. A. Waldman (2011). Barriers to, and Prospective Solutions for, Colorectal Cancer Immunotherapy. Immunogenicity. C. J. Villanueva. Hauppauge, NY, Nova Science Publishers, Inc.
  • Comber, J. D., T. M. Robinson, N. A. Siciliano, A. E. Snook and L. C. Eisenlohr (2011). "Functional macroautophagy induction by influenza A virus without a contribution to major histocompatibility complex class II-restricted presentation." J Virol 85(13): 6453-6463.
  • Lin, J. E., M. Valentino, G. Marszalowicz, M. S. Magee, P. Li, A. E. Snook, B. A. Stoecker, C. Chang and S. A. Waldman (2010). "Bacterial Heat-Stable Enterotoxins: Translation of Pathogenic Peptides into Novel Targeted Diagnostics and Therapeutics." Toxins 2(8): 2028-2054.
  • Lin, J. E., P. Li, A. E. Snook, S. Schulz, A. Dasgupta, T. M. Hyslop, A. V. Gibbons, G. Marszlowicz, G. M. Pitari and S. A. Waldman (2010). "The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling." Gastroenterology 138(1): 241-254.
  • Snook, A. E. and S. A. Waldman (2009). "Cancer Mucosa Antigens: A Novel Paradigm in Cancer Immunotherapeutics." BIOfurom Europe 13(3): 14-16.
  • Snook, A. E., P. Li, B. J. Stafford, E. J. Faul, L. Huang, R. C. Birbe, A. Bombonati, S. Schulz, M. J. Schnell, L. C. Eisenlohr and S. A. Waldman (2009). "Lineage-specific T-cell responses to cancer mucosa antigen oppose systemic metastases without mucosal inflammatory disease." Cancer Res 69(8): 3537-3544.
  • Gong, L., P. R. Debruyne, M. Witek, K. Nielsen, A. Snook, J. E. Lin, A. Bombonati, J. Palazzo, S. Schulz and S. A. Waldman (2009). "Bile acids initiate lineage-addicted gastroesophageal tumorigenesis by suppressing the EGF receptor-AKT axis." Clin Transl Sci 2(4): 286-293.
  • Chang, C., G. Marszlowicz, Z. Waldman, P. Li, A. E. Snook, J. E. Lin, S. Schulz and S. A. Waldman (2009). "Guanylyl cyclase C as a biomarker for targeted imaging and therapy of metastatic colorectal cancer." Biomark Med 3(1): 33-45.
  • Snook, A. E., B. J. Stafford, P. Li, G. Tan, L. Huang, R. Birbe, S. Schulz, M. J. Schnell, M. Thakur, J. L. Rothstein, L. C. Eisenlohr and S. A. Waldman (2008). "Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity." J Natl Cancer Inst 100(13): 950-961.
  • Snook, A. E., L. Huang, S. Schulz, L. C. Eisenlohr and S. A. Waldman (2008). "Cytokine adjuvanation of therapeutic anti-tumor immunity targeted to cancer mucosa antigens." Clin Transl Sci 1(3): 263-264.
  • Plesa, G., A. E. Snook, S. A. Waldman and L. C. Eisenlohr (2008). "Derivation and fluidity of acutely induced dysfunctional CD8+ T cells." J Immunol 180(8): 5300-5308.
  • Li, P., J. E. Lin, A. E. Snook, A. V. Gibbons, D. S. Zuzga, S. Schulz, G. M. Pitari and S. A. Waldman (2008). "Colorectal cancer is a paracrine deficiency syndrome amenable to oral hormone replacement therapy." Clin Transl Sci 1(2): 163-167.
  • Snook, A. E., B. J. Stafford, L. C. Eisenlohr, J. L. Rothstein and S. A. Waldman (2007). "Mucosally restricted antigens as novel immunological targets for antitumor therapy." Biomark Med 1(1): 187-202.
  • Snook, A. E., L. C. Eisenlohr, J. L. Rothstein and S. A. Waldman (2007). "Cancer mucosa antigens as a novel immunotherapeutic class of tumor-associated antigen." Clin Pharmacol Ther 82(6): 734-739.
  • Pitari, G. M., P. Li, J. E. Lin, D. Zuzga, A. V. Gibbons, A. E. Snook, S. Schulz and S. A. Waldman (2007). "The paracrine hormone hypothesis of colorectal cancer." Clin Pharmacol Ther 82(4): 441-447.

Last Updated by KT Ferrera: Monday, September 23, 2013 4:12:24 PM

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